《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (1): 53-55.

• 论文 • 上一篇    下一篇

Necroptosis 在中枢神经系统损伤修复中作用的研究进展

刘佳，孙天胜   

  1. 北京军区总医院全军创伤骨科研究所，北京市100700。
  • 收稿日期:2013-07-20 修回日期:2013-10-09 出版日期:2014-01-25 发布日期:2014-01-25
  • 通讯作者: 孙天胜

Role of Necroptosis in Central Nervous System Injury and Repair (review)

LIU Jia, SUN Tian-sheng.   

  1. Institute of Orthopaedics, Chinese PLA Beijing Army General Hospital, Beijing 100700, China
  • Received:2013-07-20 Revised:2013-10-09 Published:2014-01-25 Online:2014-01-25

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摘要： Necroptosis 是一种新发现的程序性细胞死亡方式，由死亡受体与其配体的结合所启动，通过特定的信号通路执行。Necroptosis已被证实参与了多种疾病的病理进程，包括肿瘤、免疫性疾病、脑外伤及脑部缺血再灌注损伤等。

关键词: necroptosis, 中枢神经系统, 程序性死亡, 脑损伤, 脊髓损伤, 修复, 综述

Abstract: Necroptosis is a newly discovered form of programmed cell death, which is activated by the binding of death receptors and their ligands and executed through specific path ways. At present, this form of cell death has been proved to be involved in a variety of diseases,such as cancer, autoimmune diseases, traumatic brain injury and brain ischemia-reperfusion injury.

Key words: necroptosis, central nervous system, programmed death, cerebral injury, spinal cord injury, repair, review