《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (07): 635-639.

• 论文 • 上一篇    下一篇

脊髓损伤相关的microRNA研究进展

陈建敏，杨拯，梁楠，张晓   

  1. 成都医学院基础医学实验教学中心，四川成都市610500。
  • 收稿日期:2012-09-21 修回日期:1900-01-01 出版日期:2013-07-25 发布日期:2013-07-25
  • 通讯作者: 张晓

Advance in MicroRNA Related with Spinal Cord Injury (review)

CHEN Jian-min, YANG Zheng, LIANG Nan, et al.   

  1. Experimental Center for Basic Medical Teaching, the School of Basic Medical Science, Chengdu Medical College, Chengdu 610500, Sichuan, China
  • Received:2012-09-21 Revised:1900-01-01 Published:2013-07-25 Online:2013-07-25

PDF (PC)

被引次数

7

摘要： 脊髓损伤是一种严重的中枢神经系统创伤。MicroRNA(miRNA)是能够抑制靶基因表达的小分子RNA，在脊髓发育和脊髓损伤等过程相关基因的调节中具有重要作用，可能是促进脊髓损伤后神经修复和再生的治疗性干预新靶点。

关键词: 脊髓损伤, microRNA, 转录后基因调控, 神经退行性变, 综述

Abstract: Spinal cord injury (SCI) is a kind of severe central nervous system trauma causing motion and/or sensation dysfunction. MicroRNAs are short non-coding RNAs that suppress the translation of target genes, and play an important role in gene regulation involved in spinal cord development and SCI, which constitute novel targets for therapeutic intervention to promote repair and regeneration.

Key words: spinal cord injury, microRNA, posttranscriptional gene regulation, neurodegeneration, review