《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (11): 1062-1065.

• 论文 • 上一篇    下一篇

伴有卵圆孔未闭的隐源性缺血性脑血管病危险因素分析

黄岳1a,2,3a，马欣1a，华扬1b，郭鸣1a,2,3b   

  1. 1.首都医科大学宣武医院，a.神经内科；b. 血管超声科，北京市100053；2. 首都医科大学康复医学院，北京市100068；3. 中国康复研究中心北京博爱医院，a.神经康复一科；b.神经内科，北京市100068。
  • 收稿日期:2012-10-10 修回日期:1900-01-01 出版日期:2012-11-25 发布日期:2012-11-25
  • 通讯作者: 马欣

Risk Factors of Cryptogenic Ischemic Cerebrovascular Disease with Patent Foramen Ovale

HUANG Yue, MA Xin, HUA Yang, et al.   

  1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2012-10-10 Revised:1900-01-01 Published:2012-11-25 Online:2012-11-25

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摘要： 目的分析并发卵圆孔未闭(PFO)的隐源性缺血性脑血管病(CICVD)患者伴随危险因素情况，探讨常见危险因素与PFO 在脑缺血发生过程中的相关性。方法连续选取2008 年1 月~2011 年7 月于首都医科大学宣武医院神经内科住院的15~70 岁CICVD患者，将其中完成经食管超声心动图检查的患者分为PFO组和非PFO组，比较两组患者的常见缺血性脑血管病危险因素，分析其与PFO的相关性。结果两组患者共102 例，其中PFO组61 例(59.80%)，非PFO组41 例(40.20%)。PFO组患者缺血性脑血管病家族史阳性者所占比例(31.1%)高于非PFO组(9.8%) (P=0.011)。两组其他观察指标无显著性差异(P>0.05)。缺血性脑血管病阳性家族史与CICVD患者伴有PFO具有相关性(r=0.251, P=0.011)。结论CICVD并发PFO比例较高，PFO的存在与缺血性脑血管病家族史具有相关性。

关键词: 脑梗死, 脑血管病, 危险因素, 卵圆孔未闭, 隐源性

Abstract: Objective To analyze the risk factors for patients with cryptogenic ischemic cerebrovascular disease (CICVD) and patent foramen ovale (PFO), as well as to evaluate the relationship between common risk factors and PFO in cerebral ischemia. Methods Consecutive patients with CICVD aged 15 to 70 years who referred to Department of Neurology, Xuanwu Hospital, Capital Medical University from January 2008 to July 2011 were investigated. Identified by transesophageal echocardiography, they were divided into PFO group and non-PFO group with respect to outcome. The common risk factors of cerebral ischemic between 2 groups were compared. The relationship between these risk factors and PFO was analyzed. Results A total of 102 patients were investigated, including 61 patients (59.80%) with PFO and 41 patients (40.20%) without PFO. Positive family history of ischemic cerebrovascular disease proportion in PFO group (31.1%)was higher than that in non-PFO group (9.8%) (P=0.011). There was no significant difference in other observed indicators (P>0.05). Positive family history of ischemic cerebrovascular disease correlated with PFO among CICVD patients (r=0.251, P=0.011). Conclusion PFO was not only more common in CICVD patients, but also correlated with positive family history of ischemic cerebrovascular disease.

Key words: infarction, cerebrovascular disorders, risk factors, patent foramen ovale, cryptogenic