《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (11): 1066-1068.

• 论文 • 上一篇    下一篇

脑白质疏松与血脂水平的关系

殷雁，王齐，张仲慧   

  1. 大连医科大学附属第二医院神经内科，辽宁大连市116027。
  • 收稿日期:2012-05-16 修回日期:1900-01-01 出版日期:2012-11-25 发布日期:2012-11-25
  • 通讯作者: 张仲慧

Relationship between Leukoaraiosis and Blood Lipid Levels

YIN Yan, WANG Qi, ZHANG Zhong-hui.   

  1. Neurology Department, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning, China
  • Received:2012-05-16 Revised:1900-01-01 Published:2012-11-25 Online:2012-11-25

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摘要： 目的探讨血脂水平与脑白质疏松的关系。方法322 例患者根据头颅MRI 分为脑白质疏松组(LA组)181 例和非脑白质疏松组(非LA组)141 例。LA组根据Fazekas 分级标准分为轻度组(Fazekas Ⅰ)57 例，中度组(Fazekas Ⅱ)52 例，重度组(Fazekas Ⅲ)72 例。比较各组间血脂水平。结果随着LA程度加重，总胆固醇水平逐渐升高(P<0.05)，中、重度组间及低密度脂蛋白胆固醇有显著性差异(P<0.05)；甘油三酯在各LA组间无显著性差异(P>0.05)，但各LA组与非LA组间均有显著性差异(P<0.05)；各组间高密度脂蛋白胆固醇水平无显著性差异(P>0.05)。结论总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平与LA发病有关，高密度脂蛋白胆固醇与LA发病无关；总胆固醇与低密度脂蛋白胆固醇与LA程度有关，甘油三酯与LA程度无关。

关键词: 脑白质疏松, 血脂, 总胆固醇, 低密度脂蛋白胆固醇, 甘油三酯

Abstract: Objective To investigate the relationship between blood lipids levels and leukoaraiosis (LA). Methods 322 cases were designed into non-LA group (n=141) and LA group (n=181) according to MRI. LA group was further designed into mild (Fazekas Ⅰ, n=57),moderate (Fazekas Ⅱ, n=52), and severe (Fazekas Ⅲ, n=72) groups according to Fazekas classification. Their blood lipids levels were compared.Results The level of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) increased (P<0.05) with the level of LA,while the level of triglycerides (TG) increased in all the LA groups (P<0.05), but no significant difference among them (P>0.05). There was no significant difference among all the groups in high-density lipoprotein cholesterol (HDL-C) (P>0.05). Conclusion TC, TG, and LDL-Cincrease in those with LA, and the TC and LDL-C increase with the severity of LA. The HDL-C do not relate with LA.

Key words: leukoaraiosis, blood lipid, total cholesterol, low-density lipoprotein cholesterol, triglycerides