《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (10): 934-938.

• 论文 • 上一篇    下一篇

药物稳定动脉粥样硬化易损斑块的研究进展

贺芬芬1,2，李哈妮2，孙芳玲1，艾厚喜1，张丽1，蒋莹1，王文1   

  1. 1. 首都医科大学宣武医院药物研究室，教育部神经变性病学重点实验室，北京市老年病医疗研究中心，北京市100053；2.华中科技大学同济医学院附属梨园医院神经内科，湖北武汉市430077
  • 收稿日期:2012-01-30 修回日期:2012-02-27 出版日期:2012-10-25 发布日期:2012-10-25
  • 通讯作者: 王文

Advance in Drug Treatment of Vulnerable Plaques in Atherosclerosis (review)

HE Fen-fen, LI Ha-ni, SUN Fang-ling, et al   

  1. Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2012-01-30 Revised:2012-02-27 Published:2012-10-25 Online:2012-10-25

PDF (PC)

被引次数

6

摘要： 动脉粥样硬化(AS)是心脑血管疾病的共同病理基础，而斑块损伤以及随之发生的血栓形成则是此类疾病致残、致死的真正元凶，如何稳定AS易损斑块一直是临床研究的热点。但目前临床用药稳定AS易损斑块的证据仍很缺乏。他汀类等多种药物虽然有效，但其副作用不容忽视。中药多环节、多靶点治疗疾病且不良反应小的特点使其在稳定AS易损斑块方面具有潜在的治疗优势。本文对药物稳定易损斑块机制的研究进展作一综述。

关键词: 动脉粥样硬化, 易损斑块, 炎症, 药物, 综述

Abstract: Atherosclerosis is the common basic pathophysiology progresses of acute cardiovascular and cerebrovascular diseases. Atherosclerotic plaque rupture and consequently thrombosis are the major cause of mobility and mortality in atherosclerosis, and treatment aimed at stabilizing vulnerable plaques is of great clinical importance. However, an ideal drug for stabilizing vulnerable plaques is still lacking. Although Statins are considered as the most potent drugs for stabilizing plaques, their side effects are serious. Traditional Chinese medicine have multi-targets and less side effect, it might be the potential candidate for atherosclerosis treatment. This article reviewed the latest progresses on the stabilizing vulnerable plaques treatments.

Key words: atherosclerosis, vulnerable plaque, inflammation, drug, review