《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (8): 724-727.

• 论文 • 上一篇    下一篇

康复训练对双侧海马梗死大鼠学习记忆能力与长时程增强的影响

赵英子，张小明，房威，何丽娟，张震   

  1. 哈尔滨242 医院，黑龙江哈尔滨市150066
  • 收稿日期:2012-02-13 修回日期:1900-01-01 出版日期:2012-08-25 发布日期:2012-08-25

Effect of Rehabilitation Training on Learning and Memory Ability and Long-term Potentiation in Rats with Bilateral Hippocampal Infarction.

ZHAO Ying-zi, ZHANG Xiao-ming, FANG Wei, et al   

  1. Harbin 242 Hospital, Harbin 150066, Heilongjiang, China
  • Received:2012-02-13 Revised:1900-01-01 Published:2012-08-25 Online:2012-08-25

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摘要： 目的探讨康复训练对双侧海马梗死大鼠记忆能力和习得性长时程增强(LTP)的影响。方法将30 只大鼠随机分为模型组、康复组及正常组，每组10 只。光化学法复制脑梗死动物模型，应用慢性埋植电极技术记录各组Y-型迷宫及被动回避反应成绩。比较学习前后海马CA3 区群体峰电位(PS)增幅及PS 潜伏期。结果康复训练后大鼠Y-型迷宫训练次数减少，被动回避潜伏期延长，PS 潜伏期缩短。结论康复训练可加快海马CA3 区习得性LTP 的形成，提高学习效率

关键词: 康复训练, 双侧海马梗死, 学习记忆能力, 长时程增强, 大鼠

Abstract: Objective To explore the effect of rehabilitation training on learning and memorial ability and long-term potentiation (LTP) in hippocampal region CA3 in rats with cerebral infarction. Methods 30 male rats were randomly divide into model group, rehabilitation training group and normal group with 10 cases in each group. Photochemical method was used to induce hippocampal infarction. The performance of Y-maze test and moving-back with current stimulation experiment were recorded. The increase rate of population spike (PS) in hippocampal region CA3 and PS latent period were compared. Results The frequency of training of Y-maze test was less after rehabilitation training, the latent period of moving-back with current stimulation experiment prolonged, and the PS latent period was shortened. Conclusion Rehabilitation training may strengthen the LTP effect in hippocampal region CA3, and improve the learning efficiency

Key words: rehabilitation training, bilateral hippocampal infarction, learning and memorial ability, long-term potentiation, rats