《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (7): 619-622.

• 论文 • 上一篇    下一篇

督脉电针对大鼠脊髓损伤后神经功能恢复的影响

李兵奎1a，曾彬2，常巍1a，王达义1a，郭振鹏1a，杨棋1a，刘涛1b   

  1. 1.湖北医药学院附属太和医院，a.脊柱外科；b.病理科，湖北十堰市442000；2.湖北医药学院附属东风公司总医院内科，湖北十堰市442000。
  • 收稿日期:2012-04-27 修回日期:1900-01-01 出版日期:2012-07-25 发布日期:2012-07-25
  • 通讯作者: 常巍

Effects of Du Meridian Electroacupuncture on Neurological Function of Rats after Spinal Cord Injury

LI Bing-kui, ZENG Bin, CHANG Wei, et al   

  1. Department of Spinal Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
  • Received:2012-04-27 Revised:1900-01-01 Published:2012-07-25 Online:2012-07-25

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被引次数

29

摘要： 目的探讨督脉电针治疗对大鼠脊髓损伤后神经功能恢复的影响。方法利用多中心急性脊髓损伤打击器建立大鼠T11脊髓损伤模型，建模成功后随机分为对照组(A组)和督脉电针组(B组)。脊髓损伤后1 周，B组接受督脉电针治疗。两组大鼠于脊髓损伤后1、2、4、8 周行BBB 后肢运动功能评分，脊髓损伤后2、4、8 周行体感诱发电位(SEP)检测，脊髓组织行HE 染色与神经丝蛋白(NF200)免疫组化染色。结果SCI 后1 周，两组大鼠BBB 后肢运动功能评分无显著性差异(P>0.05)；SCI 后2、4、8 周，B组BBB 后肢运动功能评分较A 组明显升高(P<0.01)，SEP 潜伏期明显缩短、波幅明显增高(P<0.01)。HE 染色显示损伤区瘢痕组织及空洞形成，B 组脊髓空洞比A组小；脊髓组织NF200 阳性表达B组各时间点较A组明显增强(P<0.01)。结论督脉电针治疗可有效促进SCI 大鼠神经功能恢复。

关键词: 脊髓损伤, 电针, 督脉, 体感诱发电位

Abstract: score 1, 2, 4, 8 weeks after SCI, somatosensory evoked potential (SEP) and spinal cord histopathological examination 2, 4, 8 weeks after SCI. Results The difference of BBB score was not significant between the groups 1 week after SCI (P>0.05), but improved more in group B than in group A 2,4,8 weeks after SCI (P<0.01), as well as the latency and wave amplitude of SEP (P<0.01). There were scar tissue and syringomyelia in injured spinal cord, and the size of syringomyelia was larger in group A than in group B. Neurofilament 200 (NF200) expressed 2, 4, 8 weeks after SCI, and was more in group B than in group A (P< 0.01). Conclusion Du meridian electroacupuncture can promote the recovery of neurological function in rats after spinal cord injury.

Key words: spinal cord injury, electroacupuncture, Du meridian, somatosensory evoked potential