《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (5): 470-471.

• 论文 • 上一篇    下一篇

文拉法辛缓释胶囊与帕罗西汀治疗抑郁和焦虑共病的疗效比较

禹海航1，钟海云1，刘堂龙2   

  1. 1.宁波市康宁医院，浙江宁波市 315201；2.宁波市精神病医院，浙江宁波市 315020。
  • 收稿日期:2012-02-27 修回日期:2012-03-23 出版日期:2012-05-25 发布日期:2012-05-25

Different Effects of Venlafaxine and Paroxetine on Comorbidity of Anxiety and Depression

YU Hai-hang, ZHONG Hai-yun, LIU Tang-long.   

  1. Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China
  • Received:2012-02-27 Revised:2012-03-23 Published:2012-05-25 Online:2012-05-25

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摘要： 目的比较文拉法辛缓释胶囊、帕罗西汀治疗抑郁和焦虑的共病疗效和安全性。方法86 例同时符合抑郁症和焦虑症诊断标准的住院患者，分别给予文拉法辛缓释胶囊(A组)和帕罗西汀(B组)。8 周后进行疗效评定。结果入组时两组汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分无显著性差异。治疗1 周及以后，A 组HAMD、HAMA 评分均低于B 组(P<0.05)。第8 周末A 组临床治愈率45.4%，有效率75.0%；B 组临床治愈率33.3%，有效率66.6% (P<0.05)。B 组不良反应多于A 组。结论文拉法辛缓释胶囊治疗抑郁和焦虑共病疗效优于帕罗西汀。

关键词: 文拉法辛, 帕罗西汀, 抑郁, 焦虑, 共病

Abstract: Objective To compare the efficacy and safety of venlafaxine and paroxetine in the treatment of comorbidity of depressionwith anxiety disorder. Methods 86 cases simultaneously conformed to depression and anxiety disorder accepted venlafaxine (group A) orparoxetine (group B) for 8 weeks. They were assessed with Hamilton Rating Scale for Depression (HAMD) and Hamilton Rating Scale forAnxiety (HAMA) before and 1, 2, 8 weeks after treatment. Results There was no significant difference in the scores of HAMD and HAMAbetween both groups before treatment, and there was since 1 week after treatment (P<0.05). 45.4% were clinically cured and 75.0% improvedin group A, which was 33.3% and 66.6% in group B 8 weeks after treatment (P<0.05). Conclusion Venlafaxine is more efficaciousthan paroxetine on anxiety and depression comorbidity.

Key words: venlafaxine, paroxetine, depression, anxiety, comorbidity