《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (5): 433-435.

• 论文 • 上一篇    下一篇

胰岛素及胰岛素抵抗与糖尿病认知功能障碍

郭蕾蕾，田国庆   

  1. 中国医学科学院，北京协和医学院，北京协和医院中医科，北京市 100730。
  • 收稿日期:2012-01-12 修回日期:2012-03-02 出版日期:2012-05-25 发布日期:2012-05-25

Insulin and Insulin Resistance in Diabetes with Cognitive Dysfunction (review)

GUO Lei-lei, TIAN Guo-qing.   

  1. Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China
  • Received:2012-01-12 Revised:2012-03-02 Published:2012-05-25 Online:2012-05-25

PDF (PC)

被引次数

30

摘要： 糖尿病导致的学习记忆功能障碍日益受到人们的重视。糖尿病明显增加痴呆的发生风险，包括血管性痴呆和阿尔茨海默病；糖尿病本身也可以导致患者轻、中度认知功能的下降。胰岛素水平不足和胰岛素抵抗可明显导致糖尿病认知功能障碍的发生并加速了认知功能下降的进展。

关键词: 糖尿病, 认知功能, 胰岛素, 胰岛素抵抗, 高胰岛素血症, 综述

Abstract: Learning and memory dysfunction caused by diabetes is gaining an increased attention. Diabetes can significantly increasethe risk of dementia, including vascular dementia and Alzheimer's disease; and diabetes itself can lead to mild or moderate cognition decline.Many clinical and experimental datas indicated that deficiency of insulin or insulin resistance can significantly reduce the threshold of cognitivedysfunction and accelerate the progress of cognitive decline. This paper reviewed the effect of insulin and insulin resistance on cognitivefunction in diabetes.

Key words: diabetes mellitus, cognition, insulin, insulin resistance, hyperinsulinemia, review