《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (5): 406-408.

• 论文 • 上一篇    下一篇

凝血酶激活纤溶抑制物基因启动子区-438A/G多态性与脑梗死的关系

陈煜森1，曾志良1,2，林智君1，冼文川1，钟望涛1，赵斌1，许志恩1   

  1. 1.广东医学院附属医院神经内科，广东湛江市 524001；2.东莞市太平人民医院，广东东莞市 523900。
  • 收稿日期:2012-01-06 修回日期:1900-01-01 出版日期:2012-05-25 发布日期:2012-05-25

Relationship between Promoter Polymorphism-438 A/G of Thrombin-activatable Fibrinolysis Inhibitor Gene and Cerebral Infarction

CHEN Yu-sen, ZENG Zhi-liang, LIN Zhi-jun, et al.   

  1. Department of Neurology, The Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2012-01-06 Revised:1900-01-01 Published:2012-05-25 Online:2012-05-25

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摘要： 目的分析中国汉族人群凝血酶激活纤溶抑制物基因启动子区-438A/G (TAFI-438A/G)多态性与动脉粥样硬化性脑梗死(ACI)发病的关系。方法225 例ACI 患者(病例组)和184 例健康体检者(对照组)采用聚合酶链反应-限制性内切酶片段长度多态性分析方法(PCR-RFLP)检测TAFI-438A/G 多态性。结果TAFI-438A/G 基因型及等位基因频率在病例组与对照组之间无显著性差异。性别分层后，男性脑梗死组A等位基因频率为28.6%，高于对照组20.6% (P=0.039)；AA基因型为9.0%，高于对照组1.9% (P=0.019)；在女性中无显著性差异。结论TAFI-438A/G可能与男性脑梗死的发病有关，AA基因型可能增加男性脑梗死患病风险。

关键词: 凝血酶激活纤溶抑制物, 启动子, 基因多态性, 动脉粥样硬化, 脑梗死

Abstract: Objective To research the relationship between promoter polymorphism-438 A/G of thrombin-activatable fibrinolysis inhibitorgene (TAFI-438 A/G) and atherosclerotic cerebral infarction (ACI) in Chinese Han population. Methods TAFI-438A/G genotypes andtheir allele frequencies were identified with the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in225 ACI patients and 184 healthy controls. Results There was no significant difference of TAFI-438A/G polymorphism between ACI groupand control group. Stratified by gender, in males, the incidence of A allele was 28.6% in ACI group, and 20.6% in control (P=0.039); of theAA genotype was 9.0% in ACI group, and 1.9% in control (P=0.019). But no significant difference was found in females. ConclusionTAFI-438A/G polymorphism is associated with the risk of ACI in males, that AA genotype may increase the risk of ACI.

Key words: thrombin-activatable fibrinolysis inhibitor, promoter, polymorphism, atherosclerosis, cerebral infarction.