《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (5): 419-420.

• 论文 • 上一篇    下一篇

原发性高血压患者血浆基质细胞衍生因子-1水平变化及依那普利的影响

李响，严研，李南   

  1. 首都医科大学附属北京安贞医院抢救中心，北京市 100029。
  • 收稿日期:2010-03-08 修回日期:2010-05-11 出版日期:2010-05-25 发布日期:2010-05-25
  • 通讯作者: 李南

Level of Plasma Stromal Derived Factor-1 in Essential Hypertension Patient and Effect of Enalapril on It

LI Xiang，YAN Yan，LI Nan.   

  1. Emergency Center for Heart, Lung and Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China
  • Received:2010-03-08 Revised:2010-05-11 Published:2010-05-25 Online:2010-05-25

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摘要： 目的探讨原发性高血压中血浆基质细胞衍生因子-1（SDF-1）的水平变化及血管紧张素转换酶抑制剂类药物对其的影响。方法应用酶联免疫吸附(ELISA)试验检测原发性高血压患者34例，正常健康对照组28例血浆SDF-1水平的变化。高血压患者给予依那普利治疗2周后复测血浆SDF-1。结果高血压组患者血浆SDF-1水平（4.211±1.132） mmol/L,高于健康对照组（3.568±0.936） mmol/L （P<0.05）。依那普利治疗2周后，患者血浆SDF-1水平为（4.950±1.050） mmol/L，高于治疗前（P<0.05）。结论高血压患者血浆SDF-1水平明显升高，且依那普利可增加其浓度。

关键词: 原发性高血压, 血浆基质细胞衍生因子-1, 血管紧张素转换酶抑制剂, 依那普利

Abstract: ObjectiveTo investigate the level of plasma stromal cell-derived factor-1 (SDF-1) in essential hypertension and the effect of angiotensin-converting enzyme inhibitor Enalapril on it. MethodsThe levels of plasma SDF-1 in 34 patients with hypertension and 28 normal healthy people were detected with ELISA. Hypertension patients were detected again after 2-week Enalapril treatment. ResultsThe level of SDF-1 in hypertension patients was （4.211±1.132） mmol/L, higher than control (3.568±0.936) mmol/L （P<0.05）, and became （4.950±1.050） mmol/L after treatment, higher than pre-treatment （P<0.05）. ConclusionThe level of SDF-1 increases in patients with hypertension, and Enalapril can further increase the level.

Key words: essential hypertension, stromal cell-derived factor 1, angiotensin-converting enzyme inhibitor, Enalapril