《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (4): 314-317.

• 论文 • 上一篇    下一篇

神经干细胞向多巴胺能神经元分化机制的研究进展

张可华，蔡哲   

  1. 中日友好医院临床医学研究所免疫室，北京市 100029。
  • 收稿日期:2010-03-12 修回日期:1900-01-01 出版日期:2010-04-25 发布日期:2010-04-25
  • 通讯作者: 蔡哲

Advance in Mechanism of Differentiation of Dopaminergic Neurons from Neural Stem Cells(review)

ZHANG Ke-hua, CAI Zhe.   

  1. Department of Immunology, Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029，China
  • Received:2010-03-12 Revised:1900-01-01 Published:2010-04-25 Online:2010-04-25

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被引次数

23

摘要： 帕金森病是中脑黑质的多巴胺能神经元缺失引起的慢性中枢神经系统功能失调。目前，应用神经干细胞在体内外分化成多巴胺能神经元是帕金森病细胞替代治疗的重要途径。本文综合近十年来的研究进展，对神经干细胞向多巴胺能神经元分化过程中重要的分子机制、信号通路以及外界影响因素进行综述。

关键词: 帕金森病, 神经干细胞, 多巴胺能神经元, 分化机制, 综述

Abstract: Parkinson's disease is a progressive neurodegenerative disorder in central nervous system caused by the loss of midbrain dopaminergic neurons. At present, dopaminergic neurons differentiated both in vivo and in vitro from neural stem cells act as an important cell source for the cell-replacement therapy of Parkinson's disease. This paper reviewed the major molecular mechanism, signaling pathway and important environment factors involved in differentiation of dopaminergic neurons from neural stem cells, based on the research findings in recent 10 years.

Key words: Parkinson's disease, neural stem cells, dopaminergic neuron, differentiation mechanism, review