《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (2): 103-105.

• 论文 • 上一篇    下一篇

局灶性脑缺血再灌注后神经发生及药物对其作用的研究进展

相婕1,2，许栋明3，王文1，云彩麟2，张丽1，艾厚喜1，李林1   

  1. 1.首都医科大学宣武医院药物室教育部神经变性病学重点实验室，北京市 100053；2.内蒙古医学院药学院，内蒙古呼和浩特市 010059；3.科技部火炬高技术产业开发中心，北京市 100038。
  • 收稿日期:2009-09-23 修回日期:2009-11-25 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 王文

Advance in Neurogenesis after Focal Cerebral Ischemia-reperfusion Injury and Effect of Drug (review)

XIANG Jie, XU Dong-ming, WANG Wen, et al.   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2009-09-23 Revised:2009-11-25 Published:2010-02-25 Online:2010-02-25

PDF (PC)

被引次数

1

摘要： 脑缺血是临床上常见的疾病，它能造成神经元损伤，影响神经功能。神经干细胞在一定条件下可增殖分化成神经元和胶质细胞，缺血性脑损伤后能参与神经功能的修复过程。本文对神经发生的机制和影响因素、缺血后的神经发生与脑功能恢复的联系，以及药物促进神经发生在脑缺血疾病治疗中的应用及前景进行文献综述。

关键词: 脑缺血再灌注, 神经发生, 药物, 综述

Abstract: Neural stem cells (NSCs), which will proliferate and differentiate into neurons and glial cells under certain conditions, involved in the repair of neurological function. This process is called neurogenesis. Focal cerebral ischemia-reperfusion injury is one of the most common diseases, which can induce the neurological functional deficits. It is significant to study the response and regulation of NSCs after focal cerebral ischemia-reperfusion injury. In this article, we reviewed the characteristics, molecular mechanisms, putative endogenous mediators and exogenous stimulators of neurogenesis in adult brain following ischemic injury, and response and regulation of drug in ischemic injury following neurogenesis.

Key words: cerebral ischemia-reperfusion, neurogenesis, drug, review