《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (1): 35-37.

• 论文 • 上一篇    下一篇

局部亚低温对胆红素脑病仔兔脑基底节中多巴胺及5-羟色胺的影响

王丽梅1，郝艳秋2，石丽宏1   

  1. 1.哈尔滨医科大学附属五院康复科，黑龙江大庆市 163318；2.哈尔滨医科大学附属二院儿科，黑龙江哈尔滨市 150086。
  • 收稿日期:2009-11-24 修回日期:1900-01-01 出版日期:2010-01-25 发布日期:2010-01-25

Effects of Local Mild Hypothermia on Dopamine and 5-Hydroxytryptamine in Basal Ganglion of Neonatal Rabbits with Bilirubin Encephalopathy

WANG Li-mei，HAO Yan-qiu，SHI Li-hong.   

  1. Department of Rehabilitation Medicine，The Fifth Affiliated Hospital of Harbin Medical University，Daqing 163318，Heilongjiang， china
  • Received:2009-11-24 Revised:1900-01-01 Published:2010-01-25 Online:2010-01-25

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摘要： 目的观察局部亚低温不同时间窗，胆红素脑病仔兔脑基底节区多巴胺（DA）及5-羟色胺（5-HT）含量的变化。方法建立胆红素脑病模型，对治疗组予亚低温治疗，采用荧光分光光度法，检测治疗后不同时间窗胆红素脑病仔兔脑基底节中DA及5-HT含量。结果胆红素脑病组仔兔脑基底节中DA及5-HT含量于造模后明显降低（P＜0.01）。治疗6 h、12 h、24 h后，DA及5-HT含量均明显升高（P＜0.01）。结论局部亚低温可明显减轻胆红素脑病脑组织中DA、5-HT的代谢紊乱，对脑组织具有治疗及保护作用。亚低温时间越长，效果越好。

关键词: 胆红素脑病, 亚低温, 多巴胺, 5-羟色胺

Abstract: ObjectiveTo observe the effects of local mild hypothermia at different time on dopamine (DA) and 5-hydroxytryptamine (5-HT) concentration in rabbits brain basal ganglion with bilirubin encephalopathy. MethodsThe model of bilirubin encephalopathy was established, and treated with mild hypothermia for different time. The DA and 5-HT in the basal ganglion were detected with fluorescence spectrophotometry. ResultsThe DA and the 5-HT decreased in the basal ganglion significantly after modeling (P<0.01), and increased when treated for 6 h, 12 h or 24 h (P<0.01). ConclusionLocal mild hypothermia can significantly reduce the disorder of DA and 5-HT during bilirubin encephalopathy. The longer the hypothermia, the better the effect is.

Key words: bilirubin encephalopathy, mild hypothermia, dopamine, 5-hydroxytryptamine