《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (11): 1028-1030.

• 论文 • 上一篇    下一篇

地黄苏合香合剂对早期肝性脑病大鼠一氧化氮、一氧化氮合酶、肿瘤坏死因子-α的影响

刘赫1，刘雁勇1，杨楠1，纪超1，左萍萍1，龚韬2，廖磊2，侯晓明2，蔡哲3   

  1. 1.中国医学科学院基础医学研究所；北京协和医学院基础学院药理室，北京市100005；2.北京市中药研究所中药化学室，北京市 100035；3.卫生部中日友好医院临床医学研究所免疫学研究室，北京市100029。
  • 收稿日期:2011-07-26 修回日期:2011-09-28 出版日期:2011-11-25 发布日期:2011-11-25
  • 通讯作者: 左萍萍

Effects of Rehmannia and Storesin on Nitric Oxide, Nitric Oxide Synthase and Tumor Necrosis Factor α in Early Hepatic Encephalopathy Rat Model

LIU He, LIU Yan-yong, YANG Nan, et al.   

  1. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences,Beijing 100005, China
  • Received:2011-07-26 Revised:2011-09-28 Published:2011-11-25 Online:2011-11-25

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摘要： 目的观察中药地黄、苏合香(地苏合剂)对CCl4致早期肝性脑病(HE)大鼠模型的治疗作用。方法采用灌胃给予CCl4致化学性肝损伤大鼠模型，检测大鼠血清一氧化氮(NO)含量、一氧化氮合酶(NOS)活性及大鼠海马肿瘤坏死因子-α(TNF-α)水平。结果模型组大鼠血清NO含量、NOS 活性以及海马TNF-α水平较对照组明显升高(P<0.01)；服用地苏合剂12 周后高剂量治疗组模型鼠血清NO含量、总NOS 活性以及海马TNF-α水平较模型组均明显降低(P<0.01)。结论地苏合剂可以通过降低早期HE 大鼠血清NO含量、总NOS 活性以及海马TNF-α水平延缓HE 的发生、发展。

关键词: 地黄, 苏合香, 肝性脑病, 一氧化氮, 一氧化氮合酶, 肿瘤坏死因子-α, 大鼠

Abstract: Objective To investigate the effects of Rehmannia and Storesin (RS) on early hepatic encephalopathy (HE) in rat model.Methods HE rat model was induced by CCl4 intragastric administration. The effects of RS on serum nitric oxide (NO) and nitric oxide synthase(NOS) as well as hippocampal tumor necrosis factor α (TNF-α) level of animals were evaluated in 3 dose groups. Lactulose was usedas the positive group. Results The serum NO and NOS as well as hippocampal TNF-α level of the model rats were significantly increasedcompared with that in control animals (P<0.01). The RS high dosage treatment could significantly decrease the levels of those indexes (P<0.01). Conclusion Rehmannia and Storesin is effective on early HE by decreasing the level of serum NO and NOS as well as hippocampalTNF-α.

Key words: Rehmannia, Storesin, hepatic encephalopathy, nitric oxide, nitric oxide synthase, tumor necrosis factor α, rats