《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (8): 745-747.

• 论文 • 上一篇    下一篇

二苯乙烯对2 型糖尿病大鼠降血糖作用的实验研究

杨青平1，俞发荣2，车红霞1，张梅1，胡瑞萍1，王擒虎1，石磊1   

  1. 1.甘肃省第三人民医院内分泌科，甘肃兰州市 730000；2.甘肃省证据科学技术研究与应用重点实验室，甘肃兰州市 730070。
  • 收稿日期:2011-05-20 修回日期:1900-01-01 出版日期:2011-08-25 发布日期:2011-08-25
  • 通讯作者: 俞发荣

Effect of Stilbene on Lowering Blood Glucose of Rats with Type 2 Diabetes

YANG Qing-ping, YU Fa-rong, CHE Hong-xia, et al.   

  1. Department of Endocrinology, The Third People's Hospital of Gansu Province, Lanzhou 730000, Gansu, China
  • Received:2011-05-20 Revised:1900-01-01 Published:2011-08-25 Online:2011-08-25

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被引次数

2

摘要： 目的探讨二苯乙烯对2 型糖尿病降血糖作用。方法50 只Wistar 雄性大鼠随机分为模型组(n=40)和对照组(n=10)。模型组大鼠口服脂肪乳20 ml/kg，连续40 d，分别在第41、42 天时模型组大鼠腹腔注射链脲佐菌素120 mg/kg、100 mg/kg，各1次。建立模型后，将模型组大鼠随机分为4 组，每组10 只。分别灌胃给予二苯乙烯500 mg/kg、200 mg/kg、100 mg/kg 和二甲双胍100 mg/kg。全自动生化分析仪测定血糖、血脂水平；分光光度计测肝糖元含量。结果建模后，大鼠的血糖(Glu)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平分别升高140.89%、25.77%、275.52%、105.54%和31.25% (P<0.01)；给予模型组大鼠二苯乙烯20 d 后，血糖和血脂水平比给药前降低(P<0.05)，肝糖元含量比对照组增加8.06%~16.17%。结论二苯乙烯具有降低2 型糖尿病大鼠血糖和血脂、增加肝糖元含量的作用。

关键词: 二苯乙烯, 2 型糖尿病, 血糖, 血脂

Abstract: Objective To study the effect of stilbene on blood glucose of rats with type 2 diabetes. Methods 50 male Wistar rats wererandomly divided into model group (n=40) and control group (n=10). The model group was given fat emulsion 40 days continuously with 20ml/kg, po, and streptozotocin with 120 mg/kg on the 41st day, 100 mg/kg on the 42nd day, i.p. After the modeling, the model group was dividedinto 4 groups with 10 in each. They were given stilbene with 500 ml/kg, 200 ml/kg, 100 ml/kg and metformin with 100 mg/kg, ip, respectively.The level of blood glucose, blood lipid and glycogen content were determined. Results After the modeling, the blood glucoseand TG, TC, LDL-C, HDL-C increased by 140.89%, 25.77%, 275.52%, 105.54% and 31.25% respectively (P<0.01); after stilbene was given,the level of blood glucose and lipid decreased significantly (P<0.05), the liver glycogen content increased significantly by 8.06%~16.17% compared to the control group. Conclusion Stilbene can decrease the concentration of blood glucose and lipid, and increase the liverglycogen content of rats with type 2 diabetes.

Key words: stilbene, type 2 diabetes, blood glucose, lipid