《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (8): 742-744.

• 论文 • 上一篇    下一篇

孤独症儿童血浆多不饱和脂肪酸水平研究

庞伟1a,1b，康倩倩2，郭岚敏1b,2，王景涛1b，姜志梅1b,2   

  1. 1.佳木斯大学附属第三医院，a：发育与行为儿科；b：小儿神经科，黑龙江佳木斯市 154002； 2.佳木斯大学儿童神经康复实验室，黑龙江佳木斯市 154002。
  • 收稿日期:2011-05-20 修回日期:1900-01-01 出版日期:2011-08-25 发布日期:2011-08-25
  • 通讯作者: 姜志梅

Level of Plasma Polyunsaturated Fatty Acid in Autism

PANG Wei, KANG Qian-qian, GUO Lan-min, et al.   

  1. Department of Developmental and Behavioral Pediatrics, The Third Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang, China
  • Received:2011-05-20 Revised:1900-01-01 Published:2011-08-25 Online:2011-08-25

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被引次数

20

摘要： 目的探讨孤独症儿童血浆多不饱和脂肪酸(PUFAs)水平及其与孤独症临床症状之间的相关性。方法采用高效液相色谱分析法对30 名孤独症儿童和20 名正常儿童血浆n-3 PUFAs 水平进行测定；选用Conner 儿童行为量表(父母问卷)和孤独症刻板重复行为量表(RBS-R)对其临床特征进行评定，分析n-3 PUFAs 含量与患儿行为间的关系。结果孤独症组儿童血浆中亚麻酸(ALA)、二十二碳六烯酸(DHA)以及总n-3 PUFAs 水平较正常儿童下降(P<0.05)，其中尤以DHA 含量下降最为明显(P<0.01)；n-6PUFAs 水平无明显变化。孤独症儿童血DHA 及总n-3 PUFAs 水平与冲动-多动、多动指数、学习问题、焦虑、刻板行为、自伤行为、强迫行为、仪式行为和固定行为呈负相关。结论孤独症儿童血浆PUFAs 水平比正常儿童低并与孤独症临床特征之间存在相关性。

关键词: 孤独症, 多不饱和脂肪酸, 二十二碳六烯酸, 孤独症刻板重复行为量表

Abstract: Objective To explore the level of polyunsaturated fatty acids (PUFAs) in blood plasma and its relation with the behavior ofchildren with autism. Methods High performance liquid chromatography was used to measure the level of free PUFAs of blood plasma in30 autistic children and 20 healthy children. Conner's Parent Rating Scale (parents) and the Repetitive Behavior Scale-Revised (RBS-R) RatingScale were used to evaluate the behavior of the children, and the relationship between the PUFAs level and abnormal behavior in the childrenwas also analyzed. Results The level of α-linolenic acid (ALA), docosahexenoic acid (DHA) and total n-3 PUFAs were lower in autisticchildren than in healthy children (P<0.05), especially lower in DHA (P<0.01). There was no significant difference in n-3 PUFAs betweentwo groups (P>0.05); There were negatively correlations between the level of DHA and total n-3 PUFAs in blood plasma and impulsion-hyperactivity,hyperactivity index, learning, anxiety, stereotypic behavior, self-injurious behavior, compulsions, ritualistic behavior and samenessbehavior. Conclusion The level of n-3 PUFAs in blood plasma of autistic children was lower than the healthy children and the level ofPUFAs were correlated with the behavior of autistic children.

Key words: autism, polyunsaturated fatty acids, docosahexaenoic acid, the Repetitive Behavior Scale-Revised